Assay Detail
Binding
CHEMBL684258
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Compound was evaluated for its ability to inhibit Glutamate carboxypeptidase-II using N-acetyl-L-aspartyl-[3H]L-glutamate as substrate
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Phosphonate and phosphinate analogues of N-acylated gamma-glutamylglutamate. potent inhibitors of glutamate carboxypeptidase II.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.41 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307085 | — | — | 1 | 8.52 |
| CHEMBL431954 | — | — | 1 | 8.40 |
| CHEMBL304352 | — | — | 1 | 8.40 |
| CHEMBL306014 | — | — | 1 | 8.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307085 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL431954 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL304352 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL306014 | — | IC50 | = | 5.0 | nM | 8.30 |