Assay Detail
Functional
CHEMBL684401
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for inhibition of amplification of electrically induced twitch in guinea pig ileum (GPI)
8
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Phe3-substituted analogues of deltorphin C. Spatial conformation and topography of the aromatic ring in peptide recognition by delta opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.31 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL124941 | — | — | 2 | 6.64 |
| CHEMBL124435 | — | — | 1 | 6.43 |
| CHEMBL317956 | DELTORPHIN C | — | 1 | 6.38 |
| CHEMBL121946 | — | — | 2 | - |
| CHEMBL122159 | — | — | 1 | - |
| CHEMBL330991 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL124941 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL124435 | — | IC50 | = | 369.0 | nM | 6.43 |
| CHEMBL317956 | DELTORPHIN C | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL124941 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL121946 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL121946 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL122159 | — | IC50 | > | 10.0 | nM | - |
| CHEMBL330991 | — | IC50 | > | 10.0 | nM | - |