Assay Detail
Binding
CHEMBL684407
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against binding of [125I]buserelin to human Gonadotropin-releasing hormone receptor
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Gonadotropin-releasing hormone receptor (CHEMBL1855) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Syntheses and structure-activity relationship studies of piperidine-substituted quinolones as nonpeptide gonadotropin releasing hormone antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 9.05 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48192 | — | — | 1 | 9.52 |
| CHEMBL295948 | — | — | 1 | 9.30 |
| CHEMBL300295 | — | — | 1 | 9.30 |
| CHEMBL48879 | — | — | 1 | 9.22 |
| CHEMBL52278 | — | — | 1 | 9.05 |
| CHEMBL298937 | — | — | 1 | 8.70 |
| CHEMBL51841 | — | — | 1 | 8.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48192 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL295948 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL300295 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL48879 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL52278 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL298937 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL51841 | — | IC50 | = | 5.7 | nM | 8.24 |