Assay Detail
Functional
CHEMBL684520
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Cytotoxic Activity was evaluated against H460 tumor cells
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.97 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL170758 | — | — | 1 | 9.30 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.02 |
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL170758 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL7492 | PIRITREXIM | IC50 | = | 260.0 | nM | 6.58 |