Assay Detail
Functional
CHEMBL684521
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Cytotoxic activity against non-small cell lung cancer cell line (NSCLC) H460 was determined by using MTT colorimetric assay.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Indolequinone antitumor agents: relationship between quinone structure and rate of metabolism by recombinant human NQO1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.54 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL308775 | — | — | 1 | 7.75 |
| CHEMBL359059 | — | — | 1 | 6.96 |
| CHEMBL125922 | — | — | 1 | 6.82 |
| CHEMBL126455 | — | — | 1 | 6.02 |
| CHEMBL329249 | — | — | 1 | 5.13 |
| CHEMBL78321 | — | — | 1 | - |
| CHEMBL68744 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL308775 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL359059 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL125922 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL126455 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL329249 | — | IC50 | = | 7450.0 | nM | 5.13 |
| CHEMBL78321 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL68744 | — | IC50 | > | 25000.0 | nM | - |