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Assay Detail

CHEMBL684522

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity was measured on non-small cell lung cancer(NSCLC) in H460 cell lines.
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type NCI-H460
Confidence 1 — Organism
Curated By Expert

Target

NCI-H460 (CHEMBL396)
Type CELL-LINE
Organism Homo sapiens

Publication

Indolequinone antitumor agents: correlation between quinone structure, rate of metabolism by recombinant human NAD(P)H:quinone oxidoreductase, and in vitro cytotoxicity.
Beall HD, Winski S, Swann E, Hudnott AR, Cotterill AS, O'Sullivan N, Green SJ, Bien R, Siegel D, Ross D, Moody CJ.
J Med Chem (1998) 41 : 4755 -4766
PubMed 9822546 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 6.21 7.75

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL308775 1 7.75
CHEMBL358530 1 7.03
CHEMBL306559 1 6.96
CHEMBL125922 1 6.82
CHEMBL127824 1 6.44
CHEMBL126455 1 6.02
CHEMBL357217 1 5.55
CHEMBL338521 1 5.27
CHEMBL329249 1 5.13
CHEMBL133323 1 5.10
CHEMBL68744 1 -
CHEMBL356822 1 -
CHEMBL334034 1 -
CHEMBL145291 1 -
CHEMBL78321 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL308775 IC50 = 18.0 nM 7.75
CHEMBL358530 IC50 = 93.0 nM 7.03
CHEMBL306559 IC50 = 110.0 nM 6.96
CHEMBL125922 IC50 = 150.0 nM 6.82
CHEMBL127824 IC50 = 360.0 nM 6.44
CHEMBL126455 IC50 = 960.0 nM 6.02
CHEMBL357217 IC50 = 2810.0 nM 5.55
CHEMBL338521 IC50 = 5400.0 nM 5.27
CHEMBL329249 IC50 = 7450.0 nM 5.13
CHEMBL133323 IC50 = 8000.0 nM 5.10
CHEMBL68744 IC50 > 25000.0 nM -
CHEMBL356822 IC50 > 25000.0 nM -
CHEMBL334034 IC50 > 25000.0 nM -
CHEMBL145291 IC50 > 25000.0 nM -
CHEMBL78321 IC50 > 25000.0 nM -