Assay Detail
Functional
CHEMBL684537
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Evaluated in vitro for maximal stimulatory activity for amylase release relative to CCK-8 in guinea pig tissue
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of CCK heptapeptide analogues. Effects of conformational constraints and standard modifications on receptor subtype selectivity, functional activity in vitro, and appetite suppression in vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 8.15 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL316944 | — | — | 1 | 9.19 |
| CHEMBL2310856 | — | — | 1 | 9.15 |
| CHEMBL316949 | — | — | 1 | 9.00 |
| CHEMBL318010 | — | — | 1 | 8.43 |
| CHEMBL439591 | — | — | 1 | 8.43 |
| CHEMBL412238 | — | — | 1 | 7.82 |
| CHEMBL414793 | — | — | 1 | 7.30 |
| CHEMBL98720 | — | — | 1 | 7.15 |
| CHEMBL98631 | — | — | 1 | 6.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL316944 | — | EC50 | = | 0.64 | nM | 9.19 |
| CHEMBL2310856 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL316949 | — | EC50 | = | 0.99 | nM | 9.00 |
| CHEMBL318010 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL439591 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL412238 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL414793 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL98720 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL98631 | — | EC50 | = | 140.0 | nM | 6.85 |