Assay Detail
Functional
CHEMBL684539
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Increased cAMP accumulation in isoprenaline-induced guinea pig eosinophils
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological activities of new thieno[3,2-d] pyrimidines as selective type 4 phosphodiesterase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 5.66 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL31063 | — | — | 1 | 6.70 |
| CHEMBL31530 | — | — | 1 | 6.22 |
| CHEMBL30733 | — | — | 1 | 6.16 |
| CHEMBL281244 | — | — | 1 | 5.98 |
| CHEMBL28562 | — | — | 1 | 5.77 |
| CHEMBL288545 | — | — | 1 | 5.75 |
| CHEMBL30379 | — | — | 1 | 5.75 |
| CHEMBL31795 | — | — | 1 | 5.70 |
| CHEMBL31439 | — | — | 1 | 5.68 |
| CHEMBL30966 | — | — | 1 | 5.47 |
| CHEMBL30619 | — | — | 1 | 5.46 |
| CHEMBL334988 | — | — | 1 | 5.12 |
| CHEMBL31877 | — | — | 1 | 4.75 |
| CHEMBL434822 | — | — | 1 | 4.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL31063 | — | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL31530 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL30733 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL281244 | — | EC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL28562 | — | EC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL288545 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL30379 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL31795 | — | EC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL31439 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL30966 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL30619 | — | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL334988 | — | EC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL31877 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL434822 | — | EC50 | = | 21000.0 | nM | 4.68 |