Assay Detail
Functional
CHEMBL684617
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Inhibitory activity against HIV-1 replication in mock infected H9 cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | H9 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.10 | 5.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7447 | — | — | 1 | 5.57 |
| CHEMBL273330 | — | — | 1 | 5.35 |
| CHEMBL266867 | — | — | 1 | 5.31 |
| CHEMBL273768 | — | — | 1 | 5.24 |
| CHEMBL404519 | BEVIRIMAT | 2.0 | 1 | 5.16 |
| CHEMBL268115 | — | — | 1 | 5.11 |
| CHEMBL263957 | — | — | 1 | 4.93 |
| CHEMBL108505 | DIHYDROBETULINIC ACID | — | 1 | 4.90 |
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | 4.89 |
| CHEMBL269279 | — | — | 1 | 4.88 |
| CHEMBL7365 | — | — | 1 | 4.80 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7447 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL273330 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL266867 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL273768 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL404519 | BEVIRIMAT | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL268115 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL263957 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL108505 | DIHYDROBETULINIC ACID | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL269277 | BETULINIC ACID | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL269279 | — | IC50 | = | 13100.0 | nM | 4.88 |
| CHEMBL7365 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 1875000.0 | nM | - |