Assay Detail
Functional
CHEMBL684773
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-HIV activity was evaluated as the concentration required to inhibit HIV-1 replication in H9 lymphocyte cells by 50%
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | H9 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Anti-AIDS agents. 31. Synthesis and anti-HIV activity of 4-substituted 3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (DCK) thiolactone analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.52 | 9.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269559 | — | — | 1 | 9.59 |
| CHEMBL287541 | — | — | 1 | 8.14 |
| CHEMBL433053 | — | — | 1 | 7.54 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 7.35 |
| CHEMBL431132 | — | — | 1 | 6.89 |
| CHEMBL415468 | — | — | 1 | 5.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269559 | — | EC50 | = | 0.256 | nM | 9.59 |
| CHEMBL287541 | — | EC50 | = | 7.18 | nM | 8.14 |
| CHEMBL433053 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL129 | ZIDOVUDINE | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL431132 | — | EC50 | = | 128.0 | nM | 6.89 |
| CHEMBL415468 | — | EC50 | = | 2480.0 | nM | 5.61 |