Assay Detail
Binding
CHEMBL684991
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Binding affinity for Glyoxalase I
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Role of hydrophobic interactions in binding S-(N-aryl/alkyl-N-hydroxycarbamoyl)glutathiones to the active site of the antitumor target enzyme glyoxalase I.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 6.89 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL128872 | — | — | 1 | 7.85 |
| CHEMBL127840 | — | — | 1 | 7.80 |
| CHEMBL128836 | — | — | 1 | 7.75 |
| CHEMBL131578 | — | — | 1 | 7.34 |
| CHEMBL128935 | — | — | 1 | 6.80 |
| CHEMBL129965 | — | — | 1 | 6.77 |
| CHEMBL128447 | — | — | 1 | 6.75 |
| CHEMBL129597 | — | — | 1 | 6.10 |
| CHEMBL128867 | — | — | 1 | 5.93 |
| CHEMBL129435 | — | — | 1 | 5.77 |
| CHEMBL419969 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL128872 | — | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL127840 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL128836 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL131578 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL128935 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL129965 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL128447 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL129597 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL128867 | — | Ki | = | 1180.0 | nM | 5.93 |
| CHEMBL129435 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL419969 | — | Ki | = | 183000.0 | nM | - |