Assay Detail
Functional
CHEMBL685292
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In vitro inhibitory activity was determined against Human colon tumor (HCT-8) cells.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-8 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Potential antitumor agents. 49. 5-substituted derivatives of N-[2-(dimethylamino)ethyl]-9-aminoacridine-4-carboxamide with in vivo solid-tumor activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.17 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL160719 | — | — | 1 | 8.23 |
| CHEMBL145586 | — | — | 1 | 7.96 |
| CHEMBL144980 | — | — | 1 | 7.48 |
| CHEMBL37656 | — | — | 1 | 7.18 |
| CHEMBL350028 | — | — | 1 | 7.14 |
| CHEMBL356047 | — | — | 1 | 7.05 |
| CHEMBL159135 | — | — | 1 | 6.92 |
| CHEMBL142614 | — | — | 1 | 6.31 |
| CHEMBL143532 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL160719 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL145586 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL144980 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL37656 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL350028 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL356047 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL159135 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL142614 | — | IC50 | = | 485.0 | nM | 6.31 |
| CHEMBL143532 | — | IC50 | = | 600.0 | nM | 6.22 |