Assay Detail
Binding
CHEMBL685347
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-Ro-15-4513 from GABA-A receptor alpha-6-beta-2-gamma-2 subunits expressed in Sf9 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf9 |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Expert |
Target
GABA A receptor alpha-6/beta-2/gamma-2 (CHEMBL2111370) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
High-affinity partial agonist imidazo[1,5-a]quinoxaline amides, carbamates, and ureas at the gamma-aminobutyric acid A/benzodiazepine receptor complex.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.68 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50763 | — | — | 1 | 7.89 |
| CHEMBL279867 | PANADIPLON | 2.0 | 1 | 6.22 |
| CHEMBL49888 | — | — | 1 | 5.94 |
| CHEMBL12 | DIAZEPAM | 4.0 | 1 | - |
| CHEMBL48211 | — | — | 1 | - |
| CHEMBL48403 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50763 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL279867 | PANADIPLON | Ki | = | 603.0 | nM | 6.22 |
| CHEMBL49888 | — | Ki | = | 1140.0 | nM | 5.94 |
| CHEMBL12 | DIAZEPAM | Ki | > | 7000.0 | nM | - |
| CHEMBL48211 | — | Ki | = | - | % | - |
| CHEMBL48403 | — | Ki | = | - | % | - |