Assay Detail
Binding
CHEMBL685366
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]GABA from gamma-aminobutyric-acid A (GABA-A) receptor
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
GABA-A receptor; anion channel (CHEMBL2093872) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
Structure and molecular modeling of GABAA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.39 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61683 | — | — | 1 | 7.70 |
| CHEMBL417990 | BICUCULLINE | — | 1 | 4.82 |
| CHEMBL292757 | — | — | 1 | 4.80 |
| CHEMBL1687 | — | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61683 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL417990 | BICUCULLINE | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL292757 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL1687 | — | IC50 | = | 58000.0 | nM | 4.24 |