Assay Detail
Functional
CHEMBL685387
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Cytotoxicity against H9 cell line
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | H9 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Anti-AIDS agents. 291. Anti-HIV activity of modified podophyllotoxin derivatives
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 5.90 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283631 | — | — | 1 | 7.16 |
| CHEMBL31929 | 4'-DEMETHYLEPIPODOPHYLLOTOXIN | — | 1 | 7.16 |
| CHEMBL318689 | — | — | 1 | 6.92 |
| CHEMBL100099 | — | — | 1 | 6.85 |
| CHEMBL319724 | — | — | 1 | 6.80 |
| CHEMBL319781 | — | — | 1 | 6.78 |
| CHEMBL100378 | — | — | 1 | 6.50 |
| CHEMBL32568 | — | — | 1 | 6.10 |
| CHEMBL281692 | — | — | 1 | 6.00 |
| CHEMBL1790769 | — | — | 1 | 5.90 |
| CHEMBL316950 | — | — | 1 | 5.82 |
| CHEMBL99544 | — | — | 1 | 5.82 |
| CHEMBL31839 | — | — | 1 | 5.77 |
| CHEMBL95683 | — | — | 1 | 5.77 |
| CHEMBL318054 | — | — | 1 | 5.75 |
| CHEMBL99342 | — | — | 1 | 5.73 |
| CHEMBL431418 | — | — | 1 | 5.72 |
| CHEMBL99232 | — | — | 1 | 5.18 |
| CHEMBL98908 | — | — | 1 | 5.10 |
| CHEMBL317349 | — | — | 1 | 5.05 |
| CHEMBL99324 | — | — | 1 | 5.01 |
| CHEMBL318276 | — | — | 1 | 4.54 |
| CHEMBL100325 | — | — | 1 | 4.35 |
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | - |
| CHEMBL553133 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283631 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL31929 | 4'-DEMETHYLEPIPODOPHYLLOTOXIN | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL318689 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL100099 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL319724 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL319781 | — | IC50 | = | 166.0 | nM | 6.78 |
| CHEMBL100378 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL32568 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL281692 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL1790769 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL316950 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL99544 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL31839 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL95683 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL318054 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL99342 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL431418 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL99232 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL98908 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL317349 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL99324 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL318276 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL100325 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 500000.0 | nM | - |
| CHEMBL553133 | — | IC50 | > | 100000.0 | nM | - |