Assay Detail
Binding
CHEMBL685507
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In vitro inhibition of human Glutathione Reductase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Glutathione reductase, mitochondrial (CHEMBL2755) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.82 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135536 | — | — | 1 | 6.12 |
| CHEMBL135504 | — | — | 1 | 6.00 |
| CHEMBL135287 | — | — | 1 | 5.58 |
| CHEMBL134615 | — | — | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135536 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL135504 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL135287 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL134615 | — | IC50 | = | 2700.0 | nM | 5.57 |