Assay Detail
Binding
CHEMBL685508
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Inhibitory activity against human glutathione reductase in presence of 100 uM GSSG
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Glutathione reductase, mitochondrial (CHEMBL2755) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Inhibition of human glutathione reductase by 10-arylisoalloxazines: crystalline, kinetic, and electrochemical studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.22 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39225 | — | — | 1 | 6.00 |
| CHEMBL287849 | — | — | 1 | 6.00 |
| CHEMBL39137 | — | — | 1 | 6.00 |
| CHEMBL287955 | — | — | 1 | 5.70 |
| CHEMBL39084 | — | — | 1 | 5.70 |
| CHEMBL39051 | — | — | 1 | 5.60 |
| CHEMBL290232 | — | — | 1 | 5.52 |
| CHEMBL290422 | — | — | 1 | 5.46 |
| CHEMBL39449 | — | — | 1 | 5.46 |
| CHEMBL38899 | — | — | 1 | 5.40 |
| CHEMBL39270 | — | — | 1 | 5.30 |
| CHEMBL415870 | — | — | 1 | 5.16 |
| CHEMBL39829 | — | — | 1 | 5.10 |
| CHEMBL38563 | — | — | 1 | 5.10 |
| CHEMBL289205 | — | — | 1 | 4.92 |
| CHEMBL414176 | — | — | 1 | 4.85 |
| CHEMBL418250 | — | — | 1 | 4.75 |
| CHEMBL41209 | — | — | 1 | 4.70 |
| CHEMBL290019 | — | — | 1 | 4.60 |
| CHEMBL289117 | — | — | 1 | 4.40 |
| CHEMBL38355 | — | — | 1 | 4.00 |
| CHEMBL39141 | — | — | 1 | - |
| CHEMBL287816 | — | — | 1 | - |
| CHEMBL288269 | — | — | 1 | - |
| CHEMBL40675 | — | — | 1 | - |
| CHEMBL446394 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39225 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL287849 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL39137 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL287955 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL39084 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL39051 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL290232 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL290422 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL39449 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL38899 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL39270 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL415870 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL39829 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL38563 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL289205 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL414176 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL418250 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL41209 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL290019 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL289117 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL38355 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL39141 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL287816 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL288269 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL40675 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL446394 | — | IC50 | < | 1000.0 | nM | - |