Assay Detail
Functional
CHEMBL685744
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity was evaluated against HCT-8 tumor cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-8 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 8.43 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL352960 | — | — | 1 | 9.24 |
| CHEMBL170144 | — | — | 1 | 9.23 |
| CHEMBL170758 | — | — | 1 | 9.13 |
| CHEMBL171765 | — | — | 1 | 9.12 |
| CHEMBL170760 | — | — | 1 | 9.09 |
| CHEMBL170837 | — | — | 1 | 8.89 |
| CHEMBL369258 | — | — | 1 | 8.89 |
| CHEMBL170654 | — | — | 1 | 8.85 |
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 8.74 |
| CHEMBL424170 | — | — | 1 | 8.68 |
| CHEMBL353763 | — | — | 1 | 8.51 |
| CHEMBL171305 | — | — | 1 | 8.48 |
| CHEMBL171494 | — | — | 1 | 8.36 |
| CHEMBL318721 | — | — | 1 | 8.22 |
| CHEMBL173617 | — | — | 1 | 8.13 |
| CHEMBL170900 | — | — | 1 | 8.10 |
| CHEMBL171629 | — | — | 1 | 7.28 |
| CHEMBL353929 | — | — | 1 | 7.07 |
| CHEMBL174414 | — | — | 1 | 6.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL352960 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL170144 | — | IC50 | = | 0.59 | nM | 9.23 |
| CHEMBL170758 | — | IC50 | = | 0.74 | nM | 9.13 |
| CHEMBL171765 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL170760 | — | IC50 | = | 0.82 | nM | 9.09 |
| CHEMBL170837 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL369258 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL170654 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL119 | TRIMETREXATE | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL424170 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL353763 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL171305 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL171494 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL318721 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL173617 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL170900 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL171629 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL353929 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL174414 | — | IC50 | = | 580.0 | nM | 6.24 |