Assay Detail
Binding
CHEMBL685829
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to inhibit binding of biotin-labeled human fibrinogen to immobilized fibrinogen receptor purified from human erythroleukemia (HEL) cells.
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Novel non-peptide fibrinogen receptor antagonists. 1. Synthesis and glycoprotein IIb-IIIa antagonistic activities of 1,3,4-trisubstituted 2-oxopiperazine derivatives incorporating side-chain functions of the RGDF peptide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 8.02 | 9.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL145956 | — | — | 1 | 9.68 |
| CHEMBL344544 | — | — | 1 | 9.54 |
| CHEMBL147976 | — | — | 1 | 9.38 |
| CHEMBL310081 | — | — | 1 | 9.31 |
| CHEMBL146979 | — | — | 1 | 9.05 |
| CHEMBL450621 | — | — | 1 | 9.04 |
| CHEMBL148010 | — | — | 1 | 9.04 |
| CHEMBL118402 | — | — | 1 | 9.00 |
| CHEMBL146627 | — | — | 1 | 9.00 |
| CHEMBL444861 | — | — | 1 | 8.80 |
| CHEMBL146393 | — | — | 1 | 8.71 |
| CHEMBL422486 | — | — | 1 | 8.60 |
| CHEMBL356363 | — | — | 1 | 8.32 |
| CHEMBL146784 | — | — | 1 | 8.21 |
| CHEMBL146031 | — | — | 1 | 8.09 |
| CHEMBL146523 | — | — | 1 | 7.82 |
| CHEMBL146417 | — | — | 1 | 7.79 |
| CHEMBL147921 | — | — | 1 | 7.75 |
| CHEMBL149424 | — | — | 1 | 7.75 |
| CHEMBL358154 | — | — | 1 | 7.70 |
| CHEMBL341673 | — | — | 1 | 7.70 |
| CHEMBL146721 | — | — | 1 | 7.68 |
| CHEMBL145986 | — | — | 1 | 7.43 |
| CHEMBL422132 | — | — | 1 | 7.35 |
| CHEMBL356739 | — | — | 1 | 7.34 |
| CHEMBL344506 | — | — | 1 | 7.20 |
| CHEMBL423391 | — | — | 1 | 6.96 |
| CHEMBL146323 | — | — | 1 | 6.89 |
| CHEMBL265628 | — | — | 1 | 6.75 |
| CHEMBL436405 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL145956 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL344544 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL147976 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL310081 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL146979 | — | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL450621 | — | IC50 | = | 0.91 | nM | 9.04 |
| CHEMBL148010 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL118402 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL146627 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL444861 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL146393 | — | IC50 | = | 1.95 | nM | 8.71 |
| CHEMBL422486 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL356363 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL146784 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL146031 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL146523 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL146417 | — | IC50 | = | 16.4 | nM | 7.79 |
| CHEMBL147921 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL149424 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL358154 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL341673 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL146721 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL145986 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL422132 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL356739 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL344506 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL423391 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL146323 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL265628 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL436405 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL148183 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL147553 | — | IC50 | = | 2630.0 | nM | 5.58 |