Assay Detail
Functional
CHEMBL685863
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The concentration required to produce a 50% inhibition of clone formation in human epidermoid carcinoma H-Ep-2 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEp-2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological activity of 2'-deoxy-4'-thio pyrimidine nucleosides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.71 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL445596 | 4'-THIOTHYMIDINE | — | 1 | 6.85 |
| CHEMBL1790571 | — | — | 1 | 5.68 |
| CHEMBL463660 | — | — | 1 | 4.60 |
| CHEMBL1169490 | 4'-THIO-2'-DEOXYCYTIDINE | 1.0 | 1 | - |
| CHEMBL1169491 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL445596 | 4'-THIOTHYMIDINE | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL1790571 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL463660 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL1169490 | 4'-THIO-2'-DEOXYCYTIDINE | IC50 | < | 200.0 | nM | - |
| CHEMBL1169491 | — | IC50 | < | 200.0 | nM | - |