Assay Detail
Functional
CHEMBL685872
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Inhibition of anchorage independent growth of H-ras-transformed RAT1 cells on poly(HEMA) coated microtiter plate
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | Rat1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
N-arylpiperazinone inhibitors of farnesyltransferase: discovery and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.12 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL124576 | — | — | 1 | 8.70 |
| CHEMBL125558 | — | — | 1 | 8.10 |
| CHEMBL125648 | — | — | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL124576 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL125558 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL125648 | — | IC50 | = | 28.0 | nM | 7.55 |