Assay Detail
Functional
CHEMBL686163
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its inhibition of Barium currents in GH4C1 cells.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | GH4-C1 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Permanently charged chiral 1,4-dihydropyridines: molecular probes of L-type calcium channels. Synthesis and pharmacological characterization of methyl(omega-trimethylalkylammonium) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate iodide, calcium channel antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.25 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3350227 | — | — | 1 | 5.85 |
| CHEMBL609701 | — | — | 1 | 5.82 |
| CHEMBL2092919 | — | — | 1 | 5.29 |
| CHEMBL609700 | — | — | 1 | 4.75 |
| CHEMBL2051962 | — | — | 1 | 4.55 |
| CHEMBL2111604 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3350227 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL609701 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2092919 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL609700 | — | IC50 | = | 17700.0 | nM | 4.75 |
| CHEMBL2051962 | — | IC50 | = | 28100.0 | nM | 4.55 |
| CHEMBL2111604 | — | IC50 | = | 270900.0 | nM | - |