Assay Detail
Binding
CHEMBL686300
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Inhibition of Glycogen synthase kinase-3 beta purified from insect sf9 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | insect |
| Cell Type | Sf9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Evaluation and comparison of 3D-QSAR CoMSIA models for CDK1, CDK5, and GSK-3 inhibition by paullones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.10 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296586 | KENPAULLONE | — | 1 | 7.64 |
| CHEMBL98153 | — | — | 1 | 7.62 |
| CHEMBL98554 | — | — | 1 | 6.85 |
| CHEMBL318471 | — | — | 1 | 6.70 |
| CHEMBL316940 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296586 | KENPAULLONE | IC50 | = | 23.01 | nM | 7.64 |
| CHEMBL98153 | — | IC50 | = | 23.99 | nM | 7.62 |
| CHEMBL98554 | — | IC50 | = | 139.96 | nM | 6.85 |
| CHEMBL318471 | — | IC50 | = | 199.99 | nM | 6.70 |
| CHEMBL316940 | — | IC50 | = | 199.99 | nM | 6.70 |