Assay Detail
Binding
CHEMBL686302
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inhibition of Glycogen synthase kinase-3
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Structure-based design and synthesis of 2-benzylidene-benzofuran-3-ones as flavopiridol mimics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.54 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL418203 | — | — | 1 | 6.35 |
| CHEMBL46181 | — | — | 1 | 5.76 |
| CHEMBL48362 | — | — | 1 | 5.43 |
| CHEMBL51709 | — | — | 1 | 5.38 |
| CHEMBL45477 | — | — | 1 | 5.32 |
| CHEMBL48614 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL418203 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL46181 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL48362 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL51709 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL45477 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL48614 | — | IC50 | = | 10000.0 | nM | 5.00 |