Assay Detail
Binding
CHEMBL686303
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against glycogen synthase kinase-3 (GSK-3beta).
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Thienyl and phenyl alpha-halomethyl ketones: new inhibitors of glycogen synthase kinase (GSK-3beta) from a library of compound searching.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 5.37 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL357136 | — | — | 1 | 6.30 |
| CHEMBL142826 | — | — | 1 | 6.30 |
| CHEMBL142711 | — | — | 1 | 6.00 |
| CHEMBL103009 | — | — | 1 | 6.00 |
| CHEMBL341572 | — | — | 1 | 6.00 |
| CHEMBL140061 | — | — | 1 | 6.00 |
| CHEMBL141190 | — | — | 1 | 5.82 |
| CHEMBL106072 | — | — | 1 | 5.70 |
| CHEMBL143273 | — | — | 1 | 5.70 |
| CHEMBL342402 | — | — | 1 | 5.60 |
| CHEMBL413032 | — | — | 1 | 5.60 |
| CHEMBL142824 | — | — | 1 | 5.60 |
| CHEMBL143090 | — | — | 1 | 5.60 |
| CHEMBL335357 | — | — | 1 | 5.52 |
| CHEMBL143419 | — | — | 1 | 5.30 |
| CHEMBL143743 | — | — | 1 | 5.30 |
| CHEMBL356459 | — | — | 1 | 5.30 |
| CHEMBL102953 | — | — | 1 | 5.30 |
| CHEMBL341655 | — | — | 1 | 5.10 |
| CHEMBL142764 | — | — | 1 | 5.00 |
| CHEMBL140045 | — | — | 1 | 5.00 |
| CHEMBL343821 | — | — | 1 | 4.60 |
| CHEMBL105712 | PHENACYL CHLORIDE | — | 1 | 4.30 |
| CHEMBL359135 | — | — | 1 | 4.30 |
| CHEMBL143525 | — | — | 1 | 4.30 |
| CHEMBL142327 | — | — | 1 | 4.12 |
| CHEMBL142415 | — | — | 1 | - |
| CHEMBL423377 | — | — | 1 | - |
| CHEMBL344719 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL357136 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL142826 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL142711 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL103009 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL341572 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL140061 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL141190 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL106072 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL143273 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL342402 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL413032 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL142824 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL143090 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL335357 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL143419 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL143743 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL356459 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL102953 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL341655 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL142764 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL140045 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL343821 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL105712 | PHENACYL CHLORIDE | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL359135 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL143525 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL142327 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL142415 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL423377 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL344719 | — | IC50 | > | 100000.0 | nM | - |