Assay Detail
Binding
CHEMBL686320
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Inhibition of human glycogen synthase kinase-3 beta
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.10 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL337300 | — | — | 1 | 8.05 |
| CHEMBL361708 | HYMENIALDISINE | — | 1 | 8.00 |
| CHEMBL336961 | AZAKENPAULLONE | — | 1 | 7.75 |
| CHEMBL296586 | KENPAULLONE | — | 1 | 7.64 |
| CHEMBL323657 | — | — | 1 | 6.92 |
| CHEMBL77217 | — | — | 1 | 6.12 |
| CHEMBL134501 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL337300 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL361708 | HYMENIALDISINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL336961 | AZAKENPAULLONE | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL296586 | KENPAULLONE | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL323657 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL77217 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL134501 | — | IC50 | = | 6000.0 | nM | 5.22 |