Assay Detail
Binding
CHEMBL686322
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Inhibition of Glycogen synthase kinase-3 beta
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Macrocyclic bisindolylmaleimides as inhibitors of protein kinase C and glycogen synthase kinase-3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.73 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL103506 | — | — | 1 | 8.40 |
| CHEMBL321315 | — | — | 1 | 8.40 |
| CHEMBL105477 | — | — | 1 | 8.22 |
| CHEMBL102714 | SB-216763 | — | 1 | 8.15 |
| CHEMBL105620 | — | — | 1 | 8.10 |
| CHEMBL103055 | — | — | 1 | 7.60 |
| CHEMBL103421 | — | — | 1 | 7.51 |
| CHEMBL106384 | — | — | 1 | 7.48 |
| CHEMBL321529 | — | — | 1 | 7.40 |
| CHEMBL103628 | — | — | 1 | 7.37 |
| CHEMBL106061 | — | — | 1 | 7.15 |
| CHEMBL319265 | — | — | 1 | 6.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL103506 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL321315 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL105477 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL102714 | SB-216763 | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL105620 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL103055 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL103421 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL106384 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL321529 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL103628 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL106061 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL319265 | — | IC50 | = | 110.0 | nM | 6.96 |