Assay Detail
Functional
CHEMBL686453
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Cytotoxicity expressed as the concentration that inhibited incorporation of [3H]-thymidine into cellular DNA of human lung carcinoma cells (H928)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H928 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of water-soluble glucuronide derivatives of camptothecin for cancer prodrug monotherapy and antibody-directed enzyme prodrug therapy (ADEPT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.58 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.11 |
| CHEMBL274070 | 9-AMINOCAMPTOTHECIN | 2.0 | 1 | 8.10 |
| CHEMBL405532 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL274070 | 9-AMINOCAMPTOTHECIN | IC50 | = | 7.9 | nM | 8.10 |
| CHEMBL405532 | — | IC50 | = | 300.0 | nM | 6.52 |