Assay Detail
Functional
CHEMBL686455
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity in the presence of beta-Glucuronidase (betaG, 5 micro g/ml) towards human lung carcinoma cells (H928)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H928 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of water-soluble glucuronide derivatives of camptothecin for cancer prodrug monotherapy and antibody-directed enzyme prodrug therapy (ADEPT).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.10 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL405532 | — | — | 1 | 8.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL405532 | — | IC50 | = | 7.9 | nM | 8.10 |