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Assay Detail

CHEMBL686565

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Functional
Inhibition of HIV replication was determined in H9 lymphocytes
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type H9
Confidence 1 — Organism
Curated By Intermediate

Target

H9 (CHEMBL614806)
Type CELL-LINE
Organism Homo sapiens

Publication

Anti-AIDS agents. 42. Synthesis and anti-HIV activity of disubstituted (3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone analogues.
Xie L, Takeuchi Y, Cosentino LM, McPhail AT, Lee KH.
J Med Chem (2001) 44 : 664 -671
PubMed 11262077 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 4.95 5.43

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL161576 1 5.43
CHEMBL269559 1 4.46
CHEMBL161501 1 -
CHEMBL435860 1 -
CHEMBL352285 1 -
CHEMBL349334 1 -
CHEMBL349225 1 -
CHEMBL350999 1 -
CHEMBL162529 1 -
CHEMBL423428 1 -
CHEMBL129 ZIDOVUDINE 4.0 1 -
CHEMBL161542 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL161576 IC50 = 3750.0 nM 5.43
CHEMBL269559 IC50 = 35000.0 nM 4.46
CHEMBL161501 IC50 = 135000.0 nM -
CHEMBL435860 IC50 > 140000.0 nM -
CHEMBL352285 IC50 > 150000.0 nM -
CHEMBL349334 IC50 > 154000.0 nM -
CHEMBL349225 IC50 > 154000.0 nM -
CHEMBL350999 IC50 > 154000.0 nM -
CHEMBL162529 IC50 > 147000.0 nM -
CHEMBL423428 IC50 > 148000.0 nM -
CHEMBL129 ZIDOVUDINE IC50 = 1875000.0 nM -
CHEMBL161542 IC50 = 104000.0 nM -