Assay Detail
Functional
CHEMBL686763
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Compound was evaluated for the ability to inhibit purified H+/K+ -ATPase at pH 7.4, by using gastric membrane vesicles prepared from hog stomach.
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Sus scrofa |
| Tissue | Stomach |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Antiulcer agents. 5. Inhibition of gastric H+/K(+)-ATPase by substituted imidazo[1,2-a]pyridines and related analogues and its implication in modeling the high affinity potassium ion binding site of the gastric proton pump enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.54 | 7.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296482 | — | — | 1 | 7.04 |
| CHEMBL64216 | — | — | 1 | 6.05 |
| CHEMBL47529 | — | — | 1 | 5.80 |
| CHEMBL296417 | — | — | 1 | 5.78 |
| CHEMBL293244 | — | — | 1 | 5.70 |
| CHEMBL296544 | — | — | 1 | 5.68 |
| CHEMBL137700 | — | — | 1 | 5.07 |
| CHEMBL43945 | — | — | 1 | 4.86 |
| CHEMBL137742 | — | — | 1 | 4.85 |
| CHEMBL45835 | — | — | 1 | 4.55 |
| CHEMBL136140 | — | — | 1 | - |
| CHEMBL46595 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296482 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL64216 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL47529 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL296417 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL293244 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL296544 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL137700 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL43945 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL137742 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL45835 | — | IC50 | = | 28400.0 | nM | 4.55 |
| CHEMBL136140 | — | IC50 | = | 206000.0 | nM | - |
| CHEMBL46595 | — | IC50 | = | 178000.0 | nM | - |