Assay Detail
Functional
CHEMBL686829
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Concentration required to inhibit the partially purified HDAC enzyme by 50% obtained from H1299 cell lysate
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | H1299 |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.40 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2000089 | TRAPOXIN B | — | 1 | 8.40 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 7.00 |
| CHEMBL140000 | — | — | 1 | 5.79 |
| CHEMBL143047 | — | — | 1 | 5.66 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.14 |
| CHEMBL162423 | — | — | 1 | - |
| CHEMBL165162 | — | — | 1 | - |
| CHEMBL353581 | PYROXAMIDE | 1.0 | 1 | - |
| CHEMBL164872 | — | — | 1 | - |
| CHEMBL349015 | — | — | 1 | - |
| CHEMBL57107 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2000089 | TRAPOXIN B | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL140000 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL143047 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL162423 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL165162 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL353581 | PYROXAMIDE | IC50 | > | 10000.0 | nM | - |
| CHEMBL164872 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL349015 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL57107 | — | IC50 | > | 10000.0 | nM | - |