Assay Detail
Functional
CHEMBL686884
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Inhibition of PKC-beta II mediated IL-8 release from HEK293 cells by ELISA
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Macrocyclic bisindolylmaleimides as inhibitors of protein kinase C and glycogen synthase kinase-3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.29 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL103055 | — | — | 1 | 7.60 |
| CHEMBL321315 | — | — | 1 | 7.35 |
| CHEMBL106384 | — | — | 1 | 7.34 |
| CHEMBL321529 | — | — | 1 | 7.24 |
| CHEMBL388978 | STAUROSPORINE | — | 1 | 7.11 |
| CHEMBL103628 | — | — | 1 | 7.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL103055 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL321315 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL106384 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL321529 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL103628 | — | IC50 | = | 82.0 | nM | 7.09 |