Assay Detail
Binding
CHEMBL687156
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested in vitro for inhibitory activity against HMG-CoA reductase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL402) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 9. The synthesis and biological evaluation of novel simvastatin analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.84 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3349827 | — | — | 1 | 8.12 |
| CHEMBL3349828 | — | — | 1 | 7.97 |
| CHEMBL3349544 | — | — | 1 | 7.92 |
| CHEMBL3349824 | — | — | 1 | 7.88 |
| CHEMBL333443 | — | — | 1 | 7.75 |
| CHEMBL3349825 | — | — | 1 | 7.71 |
| CHEMBL54440 | MEVASTATIN | 2.0 | 1 | 7.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3349827 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL3349828 | — | IC50 | = | 10.8 | nM | 7.97 |
| CHEMBL3349544 | — | IC50 | = | 12.1 | nM | 7.92 |
| CHEMBL3349824 | — | IC50 | = | 13.3 | nM | 7.88 |
| CHEMBL333443 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3349825 | — | IC50 | = | 19.7 | nM | 7.71 |
| CHEMBL54440 | MEVASTATIN | IC50 | = | 28.4 | nM | 7.55 |