Assay Detail
Binding
CHEMBL687159
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against isolated enzyme HMG-CoA reductase
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL2764) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Synthesis of tetrazol-1-yl analogs of HMG-COA reductase inhibitor BMS180431 (formerly BMY21950)
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.02 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL503 | LOVASTATIN | 4.0 | 1 | 7.57 |
| CHEMBL11804 | — | — | 1 | 7.37 |
| CHEMBL11891 | — | — | 1 | 6.92 |
| CHEMBL276717 | — | — | 1 | 6.20 |
| CHEMBL268767 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL503 | LOVASTATIN | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL11804 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL11891 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL276717 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL268767 | — | IC50 | > | 100000.0 | nM | - |