Assay Detail
Binding
CHEMBL687160
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HMG-coA Reductase enzyme in chinese hamster ovary cells
3
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cricetulus griseus |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL402) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
32-Methyl-32-oxylanosterols: dual-action inhibitors of cholesterol biosynthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.78 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL133434 | — | — | 1 | 6.00 |
| CHEMBL133834 | — | — | 2 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL133434 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL133834 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL133834 | — | IC50 | = | 3000.0 | nM | 5.52 |