Assay Detail
Binding
CHEMBL687311
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity towards human gonadotropin-releasing hormone receptor expressed in HEK293 cells
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | HEK293 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gonadotropin-releasing hormone receptor (CHEMBL1855) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationships of 1-arylmethyl-3-(1-methyl-2-amino)ethyl-5-aryl-6-methyluracils as antagonists of the human GnRH Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 6.51 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL111820 | — | — | 1 | 8.30 |
| CHEMBL23730 | — | — | 1 | 7.70 |
| CHEMBL112559 | — | — | 1 | 7.70 |
| CHEMBL326804 | — | — | 1 | 7.70 |
| CHEMBL23830 | — | — | 1 | 7.47 |
| CHEMBL23321 | — | — | 1 | 7.16 |
| CHEMBL23237 | — | — | 1 | 7.12 |
| CHEMBL111933 | — | — | 1 | 7.07 |
| CHEMBL111980 | — | — | 1 | 7.05 |
| CHEMBL113183 | — | — | 1 | 6.82 |
| CHEMBL113068 | — | — | 1 | 6.72 |
| CHEMBL110052 | — | — | 1 | 6.60 |
| CHEMBL114399 | — | — | 1 | 6.55 |
| CHEMBL23256 | — | — | 1 | 6.50 |
| CHEMBL432262 | — | — | 1 | 6.43 |
| CHEMBL282707 | — | — | 1 | 6.40 |
| CHEMBL112188 | — | — | 1 | 6.37 |
| CHEMBL112461 | — | — | 1 | 6.26 |
| CHEMBL325233 | — | — | 1 | 6.23 |
| CHEMBL331592 | — | — | 1 | 6.14 |
| CHEMBL114619 | — | — | 1 | 6.11 |
| CHEMBL112881 | — | — | 1 | 6.02 |
| CHEMBL112131 | — | — | 1 | 5.92 |
| CHEMBL114183 | — | — | 1 | 5.80 |
| CHEMBL419212 | — | — | 1 | 5.75 |
| CHEMBL112730 | — | — | 1 | 5.70 |
| CHEMBL112625 | — | — | 1 | 5.16 |
| CHEMBL326885 | — | — | 1 | 5.08 |
| CHEMBL114370 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL111820 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL23730 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL112559 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL326804 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL23830 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL23321 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL23237 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL111933 | — | Ki | = | 85.0 | nM | 7.07 |
| CHEMBL111980 | — | Ki | = | 90.0 | nM | 7.05 |
| CHEMBL113183 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL113068 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL110052 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL114399 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL23256 | — | Ki | = | 320.0 | nM | 6.50 |
| CHEMBL432262 | — | Ki | = | 370.0 | nM | 6.43 |
| CHEMBL282707 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL112188 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL112461 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL325233 | — | Ki | = | 590.0 | nM | 6.23 |
| CHEMBL331592 | — | Ki | = | 720.0 | nM | 6.14 |
| CHEMBL114619 | — | Ki | = | 780.0 | nM | 6.11 |
| CHEMBL112881 | — | Ki | = | 950.0 | nM | 6.02 |
| CHEMBL112131 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL114183 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL419212 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL112730 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL112625 | — | Ki | = | 7000.0 | nM | 5.16 |
| CHEMBL326885 | — | Ki | = | 8300.0 | nM | 5.08 |
| CHEMBL114370 | — | Ki | = | 15000.0 | nM | 4.82 |