Assay Detail
Binding
CHEMBL687313
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Binding affinity was determined towards human gonadotropin-releasing hormone receptor
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gonadotropin-releasing hormone receptor (CHEMBL1855) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of 1-arylmethyl-3- (2-aminoethyl)-5-aryluracil as novel gonadotropin-releasing hormone receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 15 | 6.35 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL22929 | — | — | 1 | 7.62 |
| CHEMBL60153 | — | — | 1 | 7.52 |
| CHEMBL23797 | — | — | 1 | 7.42 |
| CHEMBL303140 | — | — | 1 | 6.89 |
| CHEMBL417558 | — | — | 1 | 6.66 |
| CHEMBL23900 | — | — | 1 | 6.64 |
| CHEMBL22563 | — | — | 1 | 6.40 |
| CHEMBL60618 | — | — | 1 | 6.32 |
| CHEMBL303811 | — | — | 1 | 6.28 |
| CHEMBL64252 | — | — | 1 | 5.96 |
| CHEMBL293247 | — | — | 1 | 5.77 |
| CHEMBL304002 | — | — | 1 | 5.66 |
| CHEMBL64066 | — | — | 1 | 5.42 |
| CHEMBL64273 | — | — | 1 | 5.32 |
| CHEMBL64212 | — | — | 1 | 5.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL22929 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL60153 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL23797 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL303140 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL417558 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL23900 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL22563 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL60618 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL303811 | — | Ki | = | 530.0 | nM | 6.28 |
| CHEMBL64252 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL293247 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL304002 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL64066 | — | Ki | = | 3800.0 | nM | 5.42 |
| CHEMBL64273 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL64212 | — | Ki | = | 4800.0 | nM | 5.32 |