Assay Detail
Binding
CHEMBL687330
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Half-maximal inhibition of [125I]gastrin binding to guinea pig gastric glands
131
Total Activities
131
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Stomach |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Gastrin/cholecystokinin type B receptor (CHEMBL298) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Methods for drug discovery: development of potent, selective, orally effective cholecystokinin antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 131 | 5.34 | 7.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1907855 | — | — | 1 | 7.55 |
| CHEMBL70883 | — | — | 1 | 6.92 |
| CHEMBL9506 | DEVAZEPIDE | 2.0 | 1 | 6.77 |
| CHEMBL1907661 | — | — | 1 | 6.75 |
| CHEMBL73522 | — | — | 1 | 6.72 |
| CHEMBL2092871 | — | — | 1 | 6.62 |
| CHEMBL307661 | — | — | 1 | 6.41 |
| CHEMBL73946 | — | — | 1 | 6.41 |
| CHEMBL1907666 | — | — | 1 | 6.38 |
| CHEMBL1907841 | — | — | 1 | 6.36 |
| CHEMBL1907856 | — | — | 1 | 6.35 |
| CHEMBL1907848 | — | — | 1 | 6.28 |
| CHEMBL70593 | — | — | 1 | 6.26 |
| CHEMBL70456 | — | — | 1 | 6.19 |
| CHEMBL1907850 | — | — | 1 | 6.17 |
| CHEMBL40668 | — | — | 1 | 6.16 |
| CHEMBL39263 | — | — | 1 | 6.14 |
| CHEMBL1907851 | — | — | 1 | 6.12 |
| CHEMBL2092869 | — | — | 1 | 6.10 |
| CHEMBL1907852 | — | — | 1 | 6.10 |
| CHEMBL72526 | — | — | 1 | 5.92 |
| CHEMBL72546 | — | — | 1 | 5.89 |
| CHEMBL419764 | — | — | 1 | 5.85 |
| CHEMBL1907838 | — | — | 1 | 5.82 |
| CHEMBL303227 | — | — | 1 | 5.80 |
| CHEMBL71950 | — | — | 1 | 5.77 |
| CHEMBL305951 | — | — | 1 | 5.75 |
| CHEMBL72428 | — | — | 1 | 5.72 |
| CHEMBL1907846 | — | — | 1 | 5.70 |
| CHEMBL71079 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1907855 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL70883 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL9506 | DEVAZEPIDE | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1907661 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL73522 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2092871 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL73946 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL307661 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1907666 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL1907841 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL1907856 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL1907848 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL70593 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL70456 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL1907850 | — | IC50 | = | 680.0 | nM | 6.17 |
| CHEMBL40668 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL39263 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL1907851 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL2092869 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL1907852 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL72526 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL72546 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL419764 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1907838 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL303227 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL71950 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL305951 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL72428 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL71079 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1907846 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL302825 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1907849 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL1907853 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL2114102 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL40211 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL1907667 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL443009 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL73563 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL306760 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1907842 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL1907845 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL306806 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL73510 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2092868 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL72599 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL2092866 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL2092865 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL73885 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL441445 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL72073 | — | IC50 | = | 6700.0 | nM | 5.17 |