Assay Detail
Functional
CHEMBL687338
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In vitro antihistamine activity, by activation of guinea pig cerebral cortex adenylate cyclase by histamine mediated by both H1 and H2 receptors
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Cerebral cortex |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological properties of thiophene ring analogues of mianserin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.80 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13644 | — | — | 1 | 7.05 |
| CHEMBL13645 | — | — | 1 | 6.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13644 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL13645 | — | IC50 | = | 280.0 | nM | 6.55 |