Assay Detail
Binding
CHEMBL687538
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Compound concentration for 50% inhibition of human recombinant gelatinase A (MMP-2).
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Inhibition of Matrix Metalloproteinases: An examination of the S1 pocket
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 7.65 | 9.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59023 | — | — | 1 | 9.51 |
| CHEMBL291994 | — | — | 1 | 9.30 |
| CHEMBL294066 | — | — | 1 | 9.22 |
| CHEMBL59248 | — | — | 1 | 9.22 |
| CHEMBL292313 | — | — | 1 | 9.15 |
| CHEMBL61873 | — | — | 1 | 9.10 |
| CHEMBL62245 | — | — | 1 | 9.00 |
| CHEMBL59722 | — | — | 1 | 9.00 |
| CHEMBL62056 | — | — | 1 | 9.00 |
| CHEMBL60546 | — | — | 1 | 8.70 |
| CHEMBL303756 | — | — | 1 | 8.52 |
| CHEMBL279786 | BATIMASTAT | 2.0 | 1 | 8.40 |
| CHEMBL279785 | MARIMASTAT | 3.0 | 1 | 8.22 |
| CHEMBL58945 | — | — | 1 | 8.00 |
| CHEMBL293382 | — | — | 1 | 7.82 |
| CHEMBL264495 | — | — | 1 | 7.70 |
| CHEMBL59361 | — | — | 1 | 7.52 |
| CHEMBL60196 | — | — | 1 | 7.52 |
| CHEMBL61538 | — | — | 1 | 7.30 |
| CHEMBL58361 | — | — | 1 | 7.30 |
| CHEMBL292160 | — | — | 1 | 7.05 |
| CHEMBL58997 | — | — | 1 | 7.00 |
| CHEMBL58235 | — | — | 1 | 6.70 |
| CHEMBL61517 | — | — | 1 | 6.70 |
| CHEMBL294337 | — | — | 1 | 6.30 |
| CHEMBL416510 | — | — | 1 | 6.22 |
| CHEMBL294133 | — | — | 1 | 6.10 |
| CHEMBL418472 | — | — | 1 | 6.05 |
| CHEMBL60674 | — | — | 1 | 6.00 |
| CHEMBL59185 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59023 | — | IC50 | = | 0.31 | nM | 9.51 |
| CHEMBL291994 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL294066 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL59248 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL292313 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL61873 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL62245 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL59722 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL62056 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL60546 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL303756 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL279786 | BATIMASTAT | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL279785 | MARIMASTAT | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL58945 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL293382 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL264495 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL59361 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL60196 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL61538 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL58361 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL292160 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL58997 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL58235 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL61517 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL294337 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL416510 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL294133 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL418472 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL60674 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL59185 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL62186 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL59338 | — | IC50 | < | 0.15 | nM | - |