Assay Detail
Functional
CHEMBL687594
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti-HIV activity against acutely infected H9 lymphocytes. Activity expressed as concentration of compound toxic to 50% of mock-infected H9 cells.
40
Total Activities
40
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | H9 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Anti-AIDS agents. 34. Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 40 | 4.77 | 6.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL143038 | — | — | 1 | 6.28 |
| CHEMBL273330 | — | — | 1 | 5.34 |
| CHEMBL45857 | BETULIN-3,28-DIOXIME | — | 1 | 5.26 |
| CHEMBL217163 | — | — | 1 | 5.16 |
| CHEMBL19340 | — | — | 1 | 4.97 |
| CHEMBL263957 | — | — | 1 | 4.93 |
| CHEMBL140040 | 3-EPI-BETULIN | — | 1 | 4.91 |
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | 4.89 |
| CHEMBL434805 | — | — | 1 | 4.89 |
| CHEMBL139822 | — | — | 1 | 4.88 |
| CHEMBL282915 | — | — | 1 | 4.85 |
| CHEMBL140528 | — | — | 1 | 4.82 |
| CHEMBL140917 | — | — | 1 | 4.81 |
| CHEMBL7365 | — | — | 1 | 4.80 |
| CHEMBL142943 | — | — | 1 | 4.76 |
| CHEMBL278503 | — | — | 1 | 4.74 |
| CHEMBL23553 | — | — | 1 | 4.73 |
| CHEMBL141072 | — | — | 1 | 4.72 |
| CHEMBL359450 | — | — | 1 | 4.69 |
| CHEMBL22964 | — | — | 1 | 4.69 |
| CHEMBL143209 | — | — | 1 | 4.68 |
| CHEMBL291238 | — | — | 1 | 4.67 |
| CHEMBL356672 | — | — | 1 | 4.60 |
| CHEMBL142269 | — | — | 1 | 4.59 |
| CHEMBL139830 | — | — | 1 | 4.58 |
| CHEMBL23554 | — | — | 1 | 4.55 |
| CHEMBL266914 | — | — | 1 | 4.55 |
| CHEMBL143577 | — | — | 1 | 4.54 |
| CHEMBL16738 | — | — | 1 | 4.54 |
| CHEMBL278574 | — | — | 1 | 4.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL143038 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL273330 | — | IC50 | = | 4540.0 | nM | 5.34 |
| CHEMBL45857 | BETULIN-3,28-DIOXIME | IC50 | = | 5470.0 | nM | 5.26 |
| CHEMBL217163 | — | IC50 | = | 6990.0 | nM | 5.16 |
| CHEMBL19340 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL263957 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL140040 | 3-EPI-BETULIN | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL269277 | BETULINIC ACID | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL434805 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL139822 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL282915 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL140528 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL140917 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL7365 | — | IC50 | = | 15900.0 | nM | 4.80 |
| CHEMBL142943 | — | IC50 | = | 17500.0 | nM | 4.76 |
| CHEMBL278503 | — | IC50 | = | 18400.0 | nM | 4.74 |
| CHEMBL23553 | — | IC50 | = | 18700.0 | nM | 4.73 |
| CHEMBL141072 | — | IC50 | = | 19200.0 | nM | 4.72 |
| CHEMBL359450 | — | IC50 | = | 20600.0 | nM | 4.69 |
| CHEMBL22964 | — | IC50 | = | 20500.0 | nM | 4.69 |
| CHEMBL143209 | — | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL291238 | — | IC50 | = | 21600.0 | nM | 4.67 |
| CHEMBL356672 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL142269 | — | IC50 | = | 25800.0 | nM | 4.59 |
| CHEMBL139830 | — | IC50 | = | 26300.0 | nM | 4.58 |
| CHEMBL23554 | — | IC50 | = | 28300.0 | nM | 4.55 |
| CHEMBL266914 | — | IC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL143577 | — | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL16738 | — | IC50 | = | 29200.0 | nM | 4.54 |
| CHEMBL278574 | — | IC50 | = | 31900.0 | nM | 4.50 |
| CHEMBL143494 | — | IC50 | = | 33600.0 | nM | 4.47 |
| CHEMBL140308 | — | IC50 | = | 35300.0 | nM | 4.45 |
| CHEMBL346410 | — | IC50 | = | 36200.0 | nM | 4.44 |
| CHEMBL23236 | BETULIN | IC50 | = | 43700.0 | nM | 4.36 |
| CHEMBL297478 | BETULONAL | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL404519 | BEVIRIMAT | IC50 | > | 7000.0 | nM | - |
| CHEMBL141717 | 30-HYDROXY-BETULIN | IC50 | > | 140000.0 | nM | - |
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 500000.0 | nM | - |
| CHEMBL359080 | BETULIN DIACETATE | IC50 | > | 189800.0 | nM | - |
| CHEMBL143332 | — | IC50 | > | 133900.0 | nM | - |