Assay Detail
Functional
CHEMBL687680
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Neuroprotective effect was measured by its ability to protect mouse hippocampal neuronal HT-22 cell lines from oxidative stress caused by glutamate
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel lipoic acid analogues that inhibit nitric oxide synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.10 | 5.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33692 | — | — | 1 | 5.75 |
| CHEMBL33601 | — | — | 1 | 5.20 |
| CHEMBL34792 | — | — | 1 | 5.02 |
| CHEMBL32450 | — | — | 1 | 4.96 |
| CHEMBL32644 | — | — | 1 | 4.93 |
| CHEMBL134342 | THIOCTIC ACID | — | 1 | 4.71 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33692 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL33601 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL34792 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL32450 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL32644 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL134342 | THIOCTIC ACID | IC50 | = | 19600.0 | nM | 4.71 |