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Assay Detail

CHEMBL687736

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
The compound was tested for the concentration to inhibit 50% of HT-29 colon cells.
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HT-29
Confidence 1 — Organism
Curated By Intermediate

Target

HT-29 (CHEMBL384)
Type CELL-LINE
Organism Homo sapiens

Publication

Design of new topoisomerase II inhibitors based upon a quinobenzoxazine self-assembly model.
Zeng Q, Kwok Y, Kerwin SM, Mangold G, Hurley LH.
J Med Chem (1998) 41 : 4273 -4278
PubMed 9784102 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 6.85 7.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL137098 1 7.66
CHEMBL337526 1 7.64
CHEMBL135778 1 7.58
CHEMBL423534 1 7.55
CHEMBL334497 1 7.52
CHEMBL335700 1 7.29
CHEMBL101299 1 6.80
CHEMBL335643 1 6.75
CHEMBL335387 1 6.57
CHEMBL137263 1 6.44
CHEMBL422988 1 6.44
CHEMBL339379 1 5.70
CHEMBL337205 1 5.17

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL137098 IC50 = 22.0 nM 7.66
CHEMBL337526 IC50 = 23.0 nM 7.64
CHEMBL135778 IC50 = 26.0 nM 7.58
CHEMBL423534 IC50 = 28.0 nM 7.55
CHEMBL334497 IC50 = 30.0 nM 7.52
CHEMBL335700 IC50 = 51.0 nM 7.29
CHEMBL101299 IC50 = 160.0 nM 6.80
CHEMBL335643 IC50 = 180.0 nM 6.75
CHEMBL335387 IC50 = 270.0 nM 6.57
CHEMBL137263 IC50 = 360.0 nM 6.44
CHEMBL422988 IC50 = 360.0 nM 6.44
CHEMBL339379 IC50 = 2000.0 nM 5.70
CHEMBL337205 IC50 = 6800.0 nM 5.17