Assay Detail
Functional
CHEMBL687931
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Compound was tested for antiviral activity against human cytomegalovirus (HCMV) by plaque reduction assay using HFF cells
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HFF |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of fluorosugar analogues of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole as antivirals with potentially increased glycosidic bond stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.09 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL473894 | — | — | 1 | 6.16 |
| CHEMBL513232 | — | — | 1 | 5.54 |
| CHEMBL182 | GANCICLOVIR | 4.0 | 1 | 5.13 |
| CHEMBL2367679 | — | — | 1 | 5.10 |
| CHEMBL311377 | — | — | 1 | 5.03 |
| CHEMBL2367680 | — | — | 1 | 4.77 |
| CHEMBL2367681 | — | — | 1 | 4.64 |
| CHEMBL375530 | DICHLORORIBOBENZIMIDAZOLE | — | 1 | 4.38 |
| CHEMBL2367676 | — | — | 1 | - |
| CHEMBL2367678 | — | — | 1 | - |
| CHEMBL2367682 | — | — | 1 | - |
| CHEMBL2367677 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL473894 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL513232 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL182 | GANCICLOVIR | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL2367679 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL311377 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL2367680 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL2367681 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL375530 | DICHLORORIBOBENZIMIDAZOLE | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL2367676 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2367678 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2367682 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2367677 | — | IC50 | > | 10000.0 | nM | - |