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Assay Detail

CHEMBL688246

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Effective concentration in HRV-14 infected H1- HeLa cells by protection assay.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human rhinovirus sp.
Cell Type HeLa
Confidence 1 — Organism
Curated By Expert

Target

Human rhinovirus sp. (CHEMBL612470)
Type ORGANISM
Organism Human rhinovirus sp.

Publication

Tripeptide aldehyde inhibitors of human rhinovirus 3C protease: design, synthesis, biological evaluation, and cocrystal structure solution of P1 glutamine isosteric replacements.
Webber SE, Okano K, Little TL, Reich SH, Xin Y, Fuhrman SA, Matthews DA, Love RA, Hendrickson TF, Patick AK, Meador JW, Ferre RA, Brown EL, Ford CE, Binford SL, Worland ST.
J Med Chem (1998) 41 : 2786 -2805
PubMed 9667969 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 18 5.46 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL94652 1 6.00
CHEMBL95003 1 5.89
CHEMBL419332 1 5.89
CHEMBL96803 1 5.82
CHEMBL95120 1 5.80
CHEMBL94600 1 5.75
CHEMBL328212 1 5.70
CHEMBL97601 1 5.68
CHEMBL95007 1 5.62
CHEMBL95031 1 5.40
CHEMBL96975 1 5.40
CHEMBL96185 1 5.35
CHEMBL327370 1 5.30
CHEMBL428180 1 5.28
CHEMBL97090 1 5.10
CHEMBL97497 1 4.70
CHEMBL95173 1 4.18
CHEMBL329857 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL94652 EC50 = 1000.0 nM 6.00
CHEMBL95003 EC50 = 1300.0 nM 5.89
CHEMBL419332 EC50 = 1300.0 nM 5.89
CHEMBL96803 EC50 = 1500.0 nM 5.82
CHEMBL95120 EC50 = 1600.0 nM 5.80
CHEMBL94600 EC50 = 1800.0 nM 5.75
CHEMBL328212 EC50 = 2000.0 nM 5.70
CHEMBL97601 EC50 = 2100.0 nM 5.68
CHEMBL95007 EC50 = 2400.0 nM 5.62
CHEMBL95031 EC50 = 4000.0 nM 5.40
CHEMBL96975 EC50 = 4000.0 nM 5.40
CHEMBL96185 EC50 = 4500.0 nM 5.35
CHEMBL327370 EC50 = 5000.0 nM 5.30
CHEMBL428180 EC50 = 5200.0 nM 5.28
CHEMBL97090 EC50 = 8000.0 nM 5.10
CHEMBL97497 EC50 = 20000.0 nM 4.70
CHEMBL95173 EC50 = 66000.0 nM 4.18
CHEMBL329857 EC50 > 15800.0 nM -