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Assay Detail

CHEMBL688266

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Concentration required to inhibit uninfected H9 cell growth by 50%
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type H9
Confidence 1 — Organism
Curated By Expert

Target

H9 (CHEMBL614806)
Type CELL-LINE
Organism Homo sapiens

Publication

Anti-AIDS agents. 52. Synthesis and anti-HIV activity of hydroxymethyl (3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone derivatives.
Xie L, Yu D, Wild C, Allaway G, Turpin J, Smith PC, Lee KH.
J Med Chem (2004) 47 : 756 -760
PubMed 14736256 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 4.73 4.94

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL430615 1 4.94
CHEMBL349208 1 4.83
CHEMBL310254 1 4.64
CHEMBL431573 1 4.63
CHEMBL423448 1 4.60
CHEMBL310494 1 -
CHEMBL409338 1 -
CHEMBL306336 1 -
CHEMBL350133 1 -
CHEMBL351636 1 -
CHEMBL165487 1 -
CHEMBL350598 1 -
CHEMBL161999 1 -
CHEMBL269559 1 -
CHEMBL129 ZIDOVUDINE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL430615 IC50 = 11600.0 nM 4.94
CHEMBL349208 IC50 = 14800.0 nM 4.83
CHEMBL310254 IC50 = 23000.0 nM 4.64
CHEMBL431573 IC50 = 23600.0 nM 4.63
CHEMBL423448 IC50 = 24900.0 nM 4.60
CHEMBL310494 IC50 > 11100.0 nM -
CHEMBL409338 IC50 > 15400.0 nM -
CHEMBL306336 IC50 > 14100.0 nM -
CHEMBL350133 IC50 > 14100.0 nM -
CHEMBL351636 IC50 > 15000.0 nM -
CHEMBL165487 IC50 > 15000.0 nM -
CHEMBL350598 IC50 > 13700.0 nM -
CHEMBL161999 IC50 > 20900.0 nM -
CHEMBL269559 IC50 > 16100.0 nM -
CHEMBL129 ZIDOVUDINE IC50 = 1872000.0 nM -