Assay Detail
Functional
CHEMBL688677
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Anti viral activity against human rhinovirus (HRV) in H1HeLa cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of irreversible depsipeptidyl human rhinovirus 3C protease inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.25 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20210 | RUPINTRIVIR | 2.0 | 1 | 8.30 |
| CHEMBL315951 | — | — | 1 | 8.15 |
| CHEMBL20636 | — | — | 1 | 8.00 |
| CHEMBL417823 | — | — | 1 | 7.70 |
| CHEMBL89315 | — | — | 1 | 7.00 |
| CHEMBL19063 | — | — | 1 | 7.00 |
| CHEMBL19454 | — | — | 1 | 6.72 |
| CHEMBL329335 | — | — | 1 | 6.38 |
| CHEMBL433344 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20210 | RUPINTRIVIR | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL315951 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL20636 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL417823 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL89315 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL19063 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL19454 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL329335 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL433344 | — | EC50 | = | 1000.0 | nM | 6.00 |