Assay Detail
Binding
CHEMBL688751
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against HMG-CoA reductase from rat liver microsomal preparation
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL3247) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and biological evaluation of dihydroeptastatin, a novel inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.09 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL487720 | — | — | 1 | 8.52 |
| CHEMBL175236 | — | — | 1 | 7.89 |
| CHEMBL323880 | — | — | 1 | 7.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL487720 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL175236 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL323880 | — | IC50 | = | 14.0 | nM | 7.85 |