Assay Detail
Binding
CHEMBL688752
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of microsomal rat liver HMG-CoA reductase
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase (CHEMBL3247) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
The design and biological evaluation of a series of 3-hydroxy-3-methylglutaryl coenzyme a (HMG-CoA) reductase inhibitors related to dihydromevinolin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.28 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL306113 | — | — | 1 | 8.52 |
| CHEMBL305949 | — | — | 1 | 8.40 |
| CHEMBL73298 | — | — | 1 | 8.30 |
| CHEMBL77486 | — | — | 1 | 8.15 |
| CHEMBL72806 | — | — | 1 | 8.10 |
| CHEMBL503 | LOVASTATIN | 4.0 | 1 | 7.96 |
| CHEMBL72799 | — | — | 1 | 7.82 |
| CHEMBL75832 | — | — | 1 | 7.82 |
| CHEMBL310922 | — | — | 1 | 7.70 |
| CHEMBL309095 | — | — | 1 | 7.70 |
| CHEMBL305676 | — | — | 1 | 7.52 |
| CHEMBL76114 | — | — | 1 | 7.52 |
| CHEMBL76113 | — | — | 1 | 7.10 |
| CHEMBL76073 | — | — | 1 | 7.00 |
| CHEMBL73641 | — | — | 1 | 6.00 |
| CHEMBL431580 | — | — | 1 | 5.92 |
| CHEMBL423674 | — | — | 1 | 5.82 |
| CHEMBL430427 | — | — | 1 | 5.82 |
| CHEMBL305874 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL306113 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL305949 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL73298 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL77486 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL72806 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL503 | LOVASTATIN | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL72799 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL75832 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL310922 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL309095 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL305676 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL76114 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL76113 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL76073 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL73641 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL431580 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL423674 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL430427 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL305874 | — | IC50 | = | 6000.0 | nM | 5.22 |